Scientific Program
Scientific program
Wednesday 21st November
13:45 - 14:00 : Opening ceremony
Gilles FAVRE, Scientific director Cancéropôle Grand Sud-Ouest
14:00 - 16:00 : Plenary session
- The future of immunotherapy in oncology
Chairs: Gilles FAVRE and Nathalie BONNEFOY
- KEYNOTE SPEAKER: Aurélien MARABELLE, Gustave Roussy Institute (Paris) - Immunotherapy 2.0 : Current challenges and perspectives
- Bruno SEGUI, Cancer Research Center of Toulouse (Toulouse) - Tumor Necrosis Factor α blockade in melanoma: from basic research to the clinic and back
- Nathalie BONNEFOY, Montpellier Cancer Research Institute (Montpellier) - Development of first-in-class humanized blocking antibody targeting CD39 ectonucleotidase for combined cancer immunotherapy
- Jean-Jacques FOURNIE, Cancer Research Center of Toulouse (Toulouse) - Single cell transcriptomics unveils the distinct cytotoxic profiles of human TCRVδ1 and TCRVδ2 γδ T lymphocytes
- Henri-Alexandre MICHAUD, Montpellier Cancer Research Institute (Montpellier) - Multiplexed-epitope-based tissue imaging and single cell analysis using mass cytometry
17:00 - 19:00 : Parallel sessions organized by Canceropole GSO Axis
- Resistance and signaling / Axis 1 session
Chairs: Karine DURAND and Sébastien BRITTON
- KEYNOTE SPEAKER: Eric SAHAI, The Francis Crick Institute (London) - Role of the microenvironment in cancer invasion and therapy response
- Céline GONGORA, Montpellier Cancer Research Institute (Montpellier) - Inhibition of ATR overcomes resistance to oxaliplatin and promotes anti-tumour immunity in colorectal cancer
- Jérôme KUCHARCZAK, Montpellier Molecular Genetics Institute (Montpellier) and Université Lyon 1 (Lyon) - TRIM proteins act as a molecular rheostat to regulate the ubiquitination and anti-apoptotic activity of BCL2A1 in melanoma cells
- Olivier CALVAYRAC, Cancer Research Center of Toulouse (Toulouse) - Targeting the early steps of adaptive resistance to EGFR tyrosine-kinase inhibitors in lung cancer
- Julie DEVIN, Institute of Human Genetics (Monptellier) - Targeting DNA Repair Mechanisms to Overcome Drug Resistance in Diffuse Large B Cell Lymphoma
- Guillaume BOSSIS, Montpellier Molecular Genetics Institute (Montpellier) - Targeting SUMOylation to overcome resistance of Acute Myeloid Leukemia to chemotherapies and differentiation therapies
- Genome dynamics and cancer / Axis 2 session
Chairs: Kerstin BYSTRICKY and Malik LUTZMANN
- KEYNOTE SPEAKER: Jenny WU, Rennes Institute of Genetics and Development (Rennes) - The organization of genome duplication is a critical determinant of the landscape of genome maintenance
- Hervé SEITZ, Institute of Human Genetics (Montpellier) - Evaluation of the anti-proliferative role of the miR-34 miRNA in mammalian cells
- Justine CREFF, Laboratory of Molecular and Cellular Biology of Proliferation Control / Integrative Biology Center and Laboratory for Analyses and Architecture of Systems (Toulouse) - p57/Kip2 acts as a transcriptional regulator in colorectal cancer
- Dylane DETILLEUX, Montpellier Cell Biology Research Center (Montpellier) - Transcriptional repression of interferon-stimulated genes by the TRRAP transcriptional co-activator and its chaperone TTT
- Jérémie FAGES, Laboratory of Molecular and Cellular Biology of Proliferation Control / Integrative Biology Center (Toulouse) - JMJD6 participates in the maintenance of rDNA integrity in response to DNA damage
- Domenico MAIORANO, Institute of Human Genetics (Montpellier) - Rad18: a novel target to sensitize cancer stem cells to therapy
- Translational research, from biology to the clinic / Axis 3 session
Chairs: Majid KHATIB and Pierre CORDELIER
- Emmanuelle LIAUDET-COOPMAN, Montpellier Cancer Research Institute (Montpellier) - Cathepsin D-targeting antibodies for triple-negative breast cancer therapy
- Anthony LEMARIE, Cancer Research Center of Toulouse (Toulouse) - Inhibiting integrin β8 to differentiate and radiosensitize Glioblastoma-initiating Cells
- Alexandre EVRARD, Montpellier Cancer Research Institute (Montpellier) - Role of PXR (Pregnane X Receptor) and its target genes on the sensitivity of prostate cancer cells to tyrosine kinase inhibitors
- Eric ESPINOSA, Cancer Research Center of Toulouse (Toulouse) - Hydroxychloroquine as a novel therapeutic approach in mast cell activation diseases
- Julie GIRAUD, Bordeaux research in Translational Oncology (Bordeaux) - Development of New Mice Models of Patient Derived Orthotopic Xenograft for Studying Cancer Stem Cells Driving Gastric Cancer Metastasis
- Rita TANOS, Montpellier Cancer Research Institute (Montpellier) - Towards a screening test for cancer by circulating cell-free DNA analysis
- Gaëlle TACHON, University Hospital (Poitiers) - Prognostic significance of MEOX2 in gliomas
- Louise BAUSSARD, Epsylon - University Paul Valéry (Montpellier) - Fatigue trajectories during chemotherapy for a metastatic colorectal cancer : what are the psychosocial determiners ?
- Axel BOUKREDINE, University of Limoges (Limoges) - Involvement of TrkB transfer through exosomes in glioblastoma tumor progression
- Bases de données médico-administratives: utilisations en recherche en épidémiologie et sciences sociales / session Axe 4
Modération: Brigitte TRETARRE
- Affiche de la session>>
- ORATEURS INVITES: Philippe-Jean BOUSQUET, Institut National du Cancer (Paris) et Hélène CAILLOL, Caisse Nationale de l'Assurance Maladie (Paris)
- Intervenants GSO sélectionnés :
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- Edouard CHATIGNOUX, Santé Publique France (Toulouse) - Estimation départementale de l'incidence des cancers : comment utiliser les données médico-administratives de manière valide ?
- Sébastien ORAZIO, Bordeaux population Health (Bordeaux) - Un exemple d'utilisation des bases de données du SNIIRAM à des fins d'étude épidémiologique : proposition d'une méthode pour identifier les bénéficiaires de la CMU/CMU-C des patients inclus dans un registre des cancers.
- Nicolas THURIN, Bordeaux Population Health (Bordeaux) – Identifier des patients avec des cancers métastatiques de la prostate résistants à la castration (mCRPC) dans la base SNDS : l’étude CAMERRA
- Health technologies / Axis 5 session
Chairs: Magali GARY-BOBO and Sylvie BEGU
- KEYNOTE SPEAKERS "Nanohybrids for Cancer"
- Joël CHOPINEAU, Charles Gerhardt Institute (Montpellier) - Biological fate of silica based nanoparticles: physicochemistry and membranes interactions
- Yannick GUARI, Charles Gerhardt Institute (Montpellier) - Nanosized Prussian blue analogues as theranostic agents
- Hélène VAN DEN BERGHE, Max Mousseron Biomolecules Institute (Montpellier) - Biodegradable polymeric nanosystems for anti-cancer agent intracellular uptake
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- 8 selected talks for "Ma techno en 180 secondes" (flash posters toutes technologies)
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- Morgane DAURAT, Max Mousseron Biomolecules Institute (Montpellier) - Development of versatile biological models to study nanodevices biomedical potential
- Nizar SERHAN, Laboratory of Physics and Chemistry of Nano-Objects (Toulouse) - HSP70 inhibition and Magnetic Intra-Lysosomal Hyperthermia: a promising synergistic combination for cancer therapy
- Eric VIVES, Montpellier Cell Biology Research Center (Montpellier) - Towards multifunctional peptide-based nanoparticles for cell-delivery of siRNAs in tumors
- Nabila LAROUI, Max Mousseron Biomolecules Institute (Montpellier) - Combination of photodynamic therapy and gene silencing in cancer cells with porphyrin-siRNA complex
- Jonathan DANIEL, Institute of Molecular Science (Bordeaux) - Fluorescent soft molecular nanoparticles as nanocarrier for hydrophobic drugs. Towards novel prodrugs for glioblastoma chemotherapy
- Sofiane SAADA, University of Limoges (Limoges) - Glioblastoma Cancer Stem like Cells discrimination by UHF-Dielectrophoresis Crossover Frequency
- Frédéric FINA, Public Assistance Marseille Hospital (Marseille) - Multiplex digital PCR for the diagnostic of pilocytic astrocytoma and glioneuronal tumors
- Sylvain CUSSAT-BLANC, Institute for Advanced Technology in life science and Toulouse Informatics Research Institute (Toulouse) - Exploring Multi-Cellular Tumor Spheroids in Virtual Reality
Thursday 22nd November
08:30 - 10:30 : Plenary session and session Axe 4
- Plasticity
Chairs: Daniel FISHER and David SANTAMARIA
- KEYNOTE SPEAKER: Manuel SERRANO, Institute for Research in Biomedicine (Barcelona) - An integrative view of cellular senescence and reprogramming
- David SANTAMARIA, Actions for onCogenesis understanding and Target Identification in Oncology (Bordeaux) - Novel insights of KRAS dimerization as an essential oncogenic requirement
- Karim MROUJ, Montpellier Molecular Genetics Institute (Montpellier) - Ki-67 promotes cell plasticity and tumourigenesis by regulating global gene expression
- Jean-Philippe HUGNOT, Institute for Neurosciences of Montpellier (Montpellier) - Cellular Plasticity in Gliomas
- Jean-Emmanuel SARRY, Cancer Research Center of Toulouse (Toulouse) - Metabolic and mitochondrial flexibility in acute myeloid leukemia
- Réalité virtuelle et cancer
Modération: Nathalie BLANC et Aude MICHEL
- ORATEUR INVITE: Anne-Marie ETIENNE, Université de Liège (Liège) - La Réalité Virtuelle: quel enjeu dans les soins psychologiques en oncologie ?
- Nathalie BLANC et Aude MICHEL, Laboratoire Epsylon - Université Paul Valéry (Montpellier) - "Dessine moi une réalité plus belle": quelles perceptions du dispositif de réalité virtuelle pour les patientes atteintes d'un cancer du sein ?
- Christine LAURENT, Centre Léon Bérard (Lyon) - La réalité virtuelle au service des patients en oncologie dans le cadre de la prise en charge de l'anxiété pré-opératoire
- Thierry TALOU, Laboratoire de Chimie Agro-Industrielle, INRA (Toulouse) - Utilisation de casque aéro-audio-olfactif dans la gestion du stress en aéronautique
11:00 - 12:30 : Plenary session and session Axe 4
- Plasticity
Chairs: Julie PANNEQUIN and Fabrice LALLOUE
- KEYNOTE SPEAKER: Alain PUISIEUX, Lyon Cancer Research Center (Lyon) - Cellular pliancy and breast cancer genetics
- Anne-Claire LAVIGNE, Laboratory of Eukaryotic Molecular Biology / Integrative Biology Center (Toulouse) - Modulation of macroH2A1 isoforms during EMT process drives the metastastic potential of human prostate cancer cells
- Reini LUCO, Institute of Human Genetics (Montpellier) - Dynamic changes in chromatin regulate the highly dynamic changes in alternative splicing observed during the EMT
- Sébastien RELIER, Institute of Functional Genomics (Montpellier) - RNA epigenetic and FTO activity steer cancer cell fate
- Projets financés au sein de l'axe 4 du Cancéropôle GSO
Modération: Béatrice JACQUES
- Olivier CLAVERIE, Cancéropôle GSO - Bilan des projets financés par l'axe 4
- Sélections de projets financés:
- Virginie WOISARD, Octogone-Lordat (Toulouse) - Parolothèque
- Pascal RAGOUET, Centre Emile Durkheim (Bordeaux) - Des innovations biomédicales issues de l'aéronautique et du spatial ? Contribution à une analyse des processus translationnels en cancérologie
- Laetitia DAUBISSE MARLIAC, Registre des cancers du Tarn (Albi) - Règles d'enregistrement des tumeurs évolutives
14:30 - 16:30 : Plenary session and session Axe 4 / Axe 5
- Hepatocellular carcinoma
Chairs: Urszula HIBNER and Violaine MOREAU
- KEYNOTE SPEAKER: Jessica ZUCMAN-ROSSI, Functional Genetics of Solid Tumors (Paris) - Genomics of liver tumors: new mechanisms of carcinogenesis
- Eric ASSENAT, Montpellier Molecular Genetics Institute and University Hospital (Montpellier) - New landscape in HCC treatment : TKI and Immunotherapies
- Violaine MOREAU, Bordeaux Research in Translational Oncology (Bordeaux) - Deciphering the dual role of ß-catenin in hepatocellular carcinoma
- Bilguun ERKHEM OCHIR, Montpellier Cancer Research Institute / Gunma University Graduate School of Medicine (Gunma, Japan) - Tumor-Antagonizing Fibroblasts in hepatocellular carcinoma
- Damien GREGOIRE, Montpellier Molecular Genetics Institute (Montpellier) - CDK8 kinase acts as an oncogene in hepatocellular carcinoma
- Etudes d'innovations en santé, en collaboration avec l'Axe 5 - Technologies pour la Santé
Modération: Anne-Marie GUE
- ORATEURS INVITES: Béatrice JACQUES, Pascal RAGOUET et Philippe GORRY, Centre Emile Durkheim et Gretha (Bordeaux) - Un programme de recherche intégré et pluridisciplinaire en SHS sur une innovation, la radiologie interventionnelle: les points de vue du sociologue des sciences, de l'économiste et du sociologue de la santé
- Table ronde: présentation d'innovations en développement au sein de l'axe 5
- Marie-Pierre ROLS, Institut de Pharmacologie et de Biologie Structurale (Toulouse) - L'électrochimiothérapie: comment faire passer le courant entre la recherche et le milieu médical ?
- Audrey FERRAND, Institut de Recherche en Santé Digestive (Toulouse) - Nanoparticules dans l'alimentation humaine: existe-t'il un lien avec l'augmentation du nombre de cancers colorectaux ?
17:00 - 18:30 : Plenary session
- New publishing models
Chair: Philippe GORRY
- KEYNOTE SPEAKER: Andrea LEIBFRIED, Life Science Alliance (Germany) - Open Science & Publishing Models - how to share reproducible data
- KEYNOTE SPEAKER: Yves GINGRAS, Quebec University (Canada) & Johan GIRY, Strasbourg University (Strasbourg) - The transformation of the scientific paper : from knowledge to accounting unit
- Philippe GORRY, Gretha (Bordeaux)
18:30 - 19:15 : Plenary session
- Artificial intelligence and cancer
Chair: Claude SARDET
- KEYNOTE SPEAKER: William RITCHIE, Institute of Human Genetics (Montpellier) - Omics data in cancer : No more humans !
Friday 23rd November
08:30 - 10:15 : Parallel sessions
- Radiotherapy and DNA damage, in collaboration with SIRIC Montpellier Cancer
Chairs: David AZRIA and Malik LUTZMANN
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- KEYNOTE SPEAKER: Eric DEUTSCH, Gustave Roussy Institute (Paris) - Radiotherapy from classical DNA damage to immunotherapy
- David AZRIA, Montpellier Cancer Institute (Montpellier) - Lymphocyte apoptosis and individual radiosensitivity
- Jean-Pierre POUGET, Montpellier Cancer Research Institute (Montpellier) - Therapeutic efficacy of 177Lu-lilotomab satetraxetan in non-Hodgkin B-cell Lymphoma is controlled by G2/M cell cycle progression
- Patrick CALSOU, Institute of Pharmacology and Structural Biology (Toulouse) - Repair proteins in quest of the Ku ring: molecular insights into the first steps of DNA double-strand breaks repair by end-joining
- New mechanisms in Gastro-Intestinal Oncology
Chairs: Julie PANNEQUIN and Thibault MAZARD
- KEYNOTE SPEAKER: Philippe JAY, Institute of Functional Genomics (Montpellier) - Intestinal tuft cells: novel regulators of the immune micro-environment
- Bérengère PRADET-BALADE, Montpellier Cell Biology Research Center (Montpellier) - The HSP90 co-chaperone RPAP3 plays an essential role in intestinal homeostasis
- Pierre CORDELIER, Cancer Research Center of Toulouse (Toulouse) - H-1 parvovirus inhibits both primary tumor and metastatic growth of human pancreatic tumors
- Jean-Marc PASCUSSI, Institute of Functional Genomics (Montpellier) - miR-148a sensitizes colon cancer stem cell to chemotherapy by targeting Pregnane X- Receptor signaling
- Lisa HERON-MILHAVET, Montpellier Cancer Research Institute (Montpellier) - MAGI1 regulates anchorage-independent growth in breast and colon cancers by modulating the interaction between the HIPPO pathway regulators AMOT and YAP
10:45 - 12:30: Plenary Session
- Microbiota and cancer
Chairs: Philippe JAY and Philippe LEHOURS
- KEYNOTE SPEAKER: Joël DORE, Micalis Institute "Food and Gut Microbiology for Human Health" (Jouy-en-Josas)
- Nicolas CENAC, Digestive Health Research Institute (Toulouse) - Characterisation of bioactive lipid molecules produced by bacteria: role in intestinal homeostasis
- INVITED SPEAKER: Mathias CHAMAILLARD, Lille infection and immunology center and Pasteur Institute (Lille) - Remote control of antitumoral immunity by the gut microbiota
- Philippe LEHOURS, Bordeaux Research in Translational Oncology (Bordeaux) - Impact of Helicobacter sp infection on gastric lymphomagenesis and microbiota
