Scientific Program
Programme
Wednesday 22nd November
13:45 - 14:00 : Opening ceremony
Nadine HOUEDE, Scientific director of Cancéropôle Grand Sud-Ouest
14:00 - 15:45 : Plenary session
- Spatial biology
Chairs: Julien FAGET and Frédéric LOPEZ
- KEYNOTE SPEAKER Charles-Antoine DUTERTRE, Gustave Roussy Institute, Villejuif - Heterogeneity and spatial organisation of Tumour-Associated Mononuclear Phagocytes
- Hamid-Reza REZVANI, BoRdeaux Institute of Oncology (BRIC), Bordeaux - Single-cell analysis of skin pre-cancerous and cancerous lesions reveals differences in their metabolic profile and immune cell types
- Abdelmounim ESSABAR, Toulouse Cancer Research Center (CRCT), Toulouse - Tools for analysing spatial data in the context of immuno-oncology
15:45 - 16:05 : Plenary session
- Cancer research in Poitiers at a glance
17:15 - 18:45 : Parallel sessions organized by Cancéropôle GSO Axes
- Genome editing & CRISP'R screen / Axis 1 & Axis 2 session
Chairs: Guillaume BOSSIS and Eric JULIEN
- KEYNOTE SPEAKER Irmela JEREMIAS, Helmholz Zentrum München, Munich (Germany) - Characterizing drug targets using CRISPR/Cas9 screens in PDX leukemia models in vivo
- Aurélie BEDEL, BoRdeaux Institute of Oncology (BRIC), Bordeaux - CRISPR-Cas9 side effects: risk of genomic instability
- Dominique HELMLINGER, Centre for Biochemical and Macromolecular Research (CRBM), Montpellier - New insights into transcription co-activator functions from conditional perturbations
- Samuel AMINTAS, BoRdeaux Institute of Oncology (BRIC), Bordeaux - The CRISPR/CAS Technology for the detection of rare KRAS mutant alleles
- Therapeutic innovation and biomarkers : Flash Posters / Axis 3 session
Chairs: Véronique GIGOUX & Fabrice LALLOUE
- Diego BARBA, Montpellier Cancer Research Institute (IRCM), Montpellier - Development of pH-modulated antibodies, that recognize immune system checkpoints.
- Marie BOUTAUD, Control of cell Activation in Tumor Progression and Therapeutic Resistance, (CAPTuR) Limoges - Metformin Treatment Reduces CRC Aggressiveness in a Glucose-Independent Manner: An In Vitro and Ex Vivo Study
- David BRACQUEMOND, Montpellier Cancer Research Institute (IRCM), Montpellier - Overcoming osimertinib resistance in EGFR-driven-MET amplified lung cancer
- Lydia DIF, Bordeaux Institute of Oncology (BRIC), Bordeaux - Fascin-1 inhibitors decrease hepatoblastoma cells tumorigenicity via YAP 1
- Isabel GALEANO-OTERO, Bordeaux Institute of Oncology (BRIC), Bordeaux - Evaluation of tumor heterogeneity in colorectal cancer and its implication in metastatic process
- Gaëlle GUILLON, Montpellier Cancer Research Institute (IRCM), Montpellier - Targeting the TNBC tumour microenvironment with Exatecan-conjugated anti-Cathepsin-D ADC
- Leila KHAJAVI, Cancer Research Center of Toulouse (CRCT), Toulouse - Transcriptomic Profiling of the Non-Small Cell Lung Cancer (NSCLC) Microenvironment Identifies a Duality in Natural Killer Cell Behavior
- Fang LIU, Montpellier Cancer Research Institute (IRCM), Montpellier - Improving the TA99 immunomodulatory effect with combination therapies using a new controlled delivery technology in oncology
- Nicolas MATTEI, Pharmacology and Structural Biology Institute (IPBS), Toulouse - Study of irreversible electroporation-induced cell death in spheroids derived from a murine hepatoma cell line
- Alexia MIRANDOLA, Montpellier Cancer Research Institute (IRCM), Montpellier - Persistence of netosis in resected colon cancer patient and impact on circulating DNA applications and post-surgery colon cancer management care
- Léa RIMAILHO, Cancer Research Center of Toulouse (CRCT), Toulouse - Role of CD39 on ??T cells as a positive marker of anti-CD20-induced ADCC of non-Hodgkins lymphoma cells
- Mathis TRIQUARD, PROgression et DIssémination CErébrales des cellules Tumorales (PRODICET) Poitiers University, Poitiers - Role of Exosomes in the Brain Dissemination of Tumor Cells derived form Breast Cancer (Locoregional and Distant)
- Health technologies: Flash Posters / Axis 5 session
Chairs: Audrey FERRAND and Bertrand LIAGRE
- Israa AL JAMAL, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Poitiers - Study of cellular communication processes induced by artificial cell-cell interactions for the development of novel cell-based therapy
- Chloé BAZILE, Cancer Research Center of Toulouse (CRCT), Toulouse - Therapeutic targeting of pro-tumoral Tumor-Associated Macrophage by vectorized anti-folate receptor beta magnetic nanoparticles
- Manon PORTA, LIttoral, ENvironment and Societies (LIENSs), La Rochelle - Bioactive ?-Carrageenan oligosaccharides coated ferrite nanoparticles as potential anticancer nanodrugs
- Marcelo HURTADO, Cancer Research Center of Toulouse (CRCT), Toulouse - Transcriptional regulatory networks unravel cell states from immune cell type deconvolution and uncovers cell niches predictive of cancer progression
- Aurélien MAZET, Laboratory for the Bioengineering of Tissues (BioTis), Bordeaux - Bioprinting early-stage pancreatic cancer models: a new tool to decipher tumor initiation mechanisms
- Camille DOUILLET, Photonics, Numerical and Nanosciences Laboratory (LP2N), Bordeaux - Gut-in-caps: exploring the biophysical cues that drive self-organization of Caco2 cells into patho-physiological models of the intestinal epithelium
- Malvina MARKU, Cancer Research Center of Toulouse (CRCT), Toulouse - From gene regulatory network inference to dynamical modelling: revealing cell behaviour through network modelling in Chronic Lymphocytic Leukaemia
Thursday 23rd November
09:00 - 11:00 : Plenary session
- Chemistry & Cancer
Chairs: Bertrand LIAGRE and Philippe POURQUIER
- KEYNOTE SPEAKER Dario NERI, ETH, Zürich (Switzerland) - From encoded combinatorial libraries to clinical-stage targeted therapeutics
- Marie LOPEZ, ETaC, Toulouse and Institut des Biomolécules Max Mousseron (IBMM), Montpellier - GRP94 chaperone identified as a new target of adenosine-cytosine bisustrate analogues in cancer cells using affinity based chemical probes
- Justine JOURNAUX, Toulouse Cancer Research Center (CRCT), Toulouse - Thermal and mechanical stresses generated by magnetic nanoparticles upon magnetic field exposure induce immunogenic cell death in pancreatic adenocarcinoma
- David LEGER, Laboratoire des Agroressources, Biomolécules et Chimie pour l'Innovation en Santé (LABCiS), Limoges - Effects of metalation on the PDT activity of arene ruthenium porphyrin-based photosensitizers on prostate cancer
- Sébastien BRITTON, Pharmacology and Structural Biology Institute (IPBS), Toulouse - Deciphering and exploiting the mechanism of action of a large family of natural and bioinspired cytotoxic lipids
14:00 - 16:00 : Parallel sessions organized by Cancéropôle GSO Axes
- Cell signaling, microenvironment and targeting / Axis 1 session
Chairs: Violaine MOREAU and Antonio MARAVER
- KEYNOTE SPEAKER Roger GOMIS, Institute for Research in Biomedicine, Barcelona (Spain) - ER+ breast cancer metastasis cell fate mapping
- Benoît THIBAULT, Toulouse Cancer Research Center (CRCT), Toulouse - Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation
- Jennifer FALCONI, Institut de Recherche en Cancérologie de Montpellier (IRCM), Montpellier - Tumor-derived cytokine, Upd3, promotes gut atrophy in a Drosophila larvae model of cachexia
- Thomas BOYER, Immunoconcept, Bordeaux - Immunosuppressive Myeloid Cells foster Cancer Stem Cell (CSC) emergence through TGF-?
- Lucile ROUYER, BoRdeaux Institute of Oncology (BRIC), Bordeaux - Cancer cells transfer invasive properties through tracks
- Gilles FAVRE, Toulouse Cancer Research Center (CRCT), Toulouse - In silico-based strategy for the discovery of direct small molecule inhibtors of mutant RAS
- Genome Dynamics & Expression / Axis 2 session
Chairs: Jean-Christophe ANDRAU and Derek McCUSKER
- KEYNOTE SPEAKER Francis BARR, Trinity College & University of Oxford, Oxford (United Kingdom) - Mitotic mechanisms generating and sensing aneuploidy
- Frédéric BECKOUET, Center for Integrative Biology (CBI), Toulouse - Mechanisms regulating cohesin dependent loops
- Nezih KARASU, Institute of Molecular Genetics of Montpellier (IGMM), Montpellier - G-quadruplexes involvement in mammalian genome organization and stability
- Sophie PERON, Control of the Immune B Response and Lymphoproliferations (CRIBL), Limoges - IgH 3'RR recombination uncovers a non-germinal center imprint and c-MYC-dependent IgH rearrangement in unmutated chronic lymphocytic leukemia
- Domitille CHALOPIN-FILLOT, Institute of Cellular Biochemistry and Genetics (IBGC), Bordeaux - Exploiting the dark matter of single-cell transcriptomes to encompass suppressive myeloid cell differentiation in hepatocellular carcinoma
- Nouveaux dispositifs numériques (in french) / session Axe 4
- 1 orateur invité
- 3 communications sélectionnées
17:00 - 18:30 : Plenary session
- Environmental stress
Chair: Cyrille DELPIERRE
- KEYNOTE SPEAKER Marc CHADEAU-HYAM, Imperial College, London (United Kingdom) - Exposome Analytics: Definitions, Challenges and Applications
18:30 - 19:30 :
- Prestige conference
- KEYNOTE SPEAKER Jacques ARNOULD, French Spatial Agency (CNES), Toulouse
Friday 24th November
08:30 - 10:00 : Parallel sessions organized by Cancéropôle GSO Axes
- Immunotherapy / Axis 1 & Axis 3 session
Chairs: Abdel-Majid KHATIB & Bruno SEGUI
- KEYNOTE SPEAKER Joan SEOANE, Vall d'Hebron Institute of Oncology (VHIO) & Universitat Autònoma de Barcelona (UAB), Barcelona (Spain) - Understanding the impact of the tumor microenvironment on immunotherapies
- Nicolas LARMONIER, BoRdeaux Institute of Oncology (BRIC), Bordeaux - The multifaceted tumor-promoting functions of myeloid cells
- Ludovic MARTINET, Toulouse Cancer Research Center (CRCT), Toulouse - T cell Immunotherapy: thinking beyond inhibitory receptors
- Camille DANTZER, BoRdeaux Institute of Oncology (BRIC), Bordeaux - Repression of exosome secretion by mutated ß-catenin contributes to immune escape in hepatocellular carcinoma
- Patients fragiles ou patients vulnérables (1) (in french) / session Axe 4
- 1 orateur invité
- 2 communications sélectionnées
10:45 - 12:30: Plenary session and session Axe 4
- Alternative models to animal testing
Chairs: Audrey FERRAND and Gaëlle RECHER
- KEYNOTE SPEAKER Agathe FIGAROL, Institut FEMTO-ST, Besançon - Development of a physiological microsystem, from a blood-brain barrier-on-chip to a vascularized glioblastoma-on-chip
- Léa MAGNE, Institut de Recherche en Santé Digestive (IRSD), Toulouse - Mechanical interplays between mitotic spindle orientation of colonic epithelial cells and extracellular matrix deformations
- Margot MACHU, Institut de Recherche en Cancérologie de Montpellier (IRCM), Montpellier - Combination of immune checkpoint inhibitors with chemotherapies in new biological models of upper tract urothelial carcinomas
- Alexia DE CARO, Institute of Pharmacology and Structural Biology (IPBS), Toulouse - Anti-tumor efficacy of new high-frequency electrical protocols in a 3D in vitro colorectal cancer model
- Thomas BESSEDE, Institut de Recherche en Cancérologie de Montpellier (IRCM), Montpellier - Sensitizing the PDAC tumor microenvironment to immune checkpoint therapies: characterization of a PDAC 3D model to decipher immune infiltration
- Joudi EL MIR, BoRdeaux Institute of Oncology (BRIC), Bordeaux - Xenopus laevis is an attractive model for studying the pigmentary abnormalities in xeroderma pigmentosum type C
- Patients fragiles ou patients vulnérables (2) (in french) / session Axe 4
- 1 orateur invité
- 2 communications sélectionnées
