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Scientific Program




Wednesday November 22nd
13:45-14:00 Opening ceremony
14:00-15:45 Spatial biology 
15:45-16:05 Cancer research in Poitiers at a glance
16:05-17:15 Poster session (1)
Genome editing & Crisp'R Screen   Therapeutic innovation and biomarkers   Health technologies
18:45-20:00 Icebreaker: Drinks & Posters
20:30-23:00 Speaker and moderator dinner (upon invitation)


Thursday November 23rd
08:30-10:15 Chemistry & Cancer
10:15-11:15 Poster session (2)
11:15-12:45 Methods, management and data analysis
12:45-14:15 Lunch
Cell signaling, microenvironment and targeting   Genome Dynamics & Expression   Nouveaux dispositifs numériques (in french)
16:00-17:00 Break
17:00-18:30 Environmental stress
18:30-19:30 Prestige conference
20:00 Gala dinner, social event (upon registration)


Friday November 24th
Patients fragiles ou patients vulnérables (1) (in french)
10:00-11:00 Break
11:00-12:45 Alternative models to animal testing  
Patients fragiles ou patients vulnérables (2) (in french)
12:45-13:00 Poster Awards - Closing ceremony
13:00-14:00 Closing cocktail


Wednesday 22nd November

13:45 - 14:00 : Opening ceremony

Nadine HOUEDE, Scientific director of Cancéropôle Grand Sud-Ouest


14:00 - 15:45 : Plenary session

  •  Spatial biology
    Chairs: Julien FAGET and Frédéric LOPEZ
    • KEYNOTE SPEAKER Charles-Antoine DUTERTRE, Gustave Roussy Institute, Villejuif - Heterogeneity and spatial organisation of Tumour-Associated Mononuclear Phagocytes
    • Hamid-Reza REZVANI, BoRdeaux Institute of Oncology (BRIC), BordeauxSingle-cell analysis of skin pre-cancerous and cancerous lesions reveals differences in their metabolic profile and immune cell types
    • Abdelmounim ESSABAR, Toulouse Cancer Research Center (CRCT), Toulouse - Tools for analysing spatial data in the context of immuno-oncology


15:45 - 16:05 : Plenary session

  •  Cancer research in Poitiers at a glance
    • Aubin PENNA, Laboratory Channels and Connexins in Cancer and Cell Stemness (4CS), Poitiers  


17:15 - 18:45 : Parallel sessions organized by Cancéropôle GSO Axes

  •  Genome editing & CRISP'R screen / Axis 1 & Axis 2 session
    Chairs: Guillaume BOSSIS and Eric JULIEN
    • KEYNOTE SPEAKER Irmela JEREMIASHelmholz Zentrum München, Munich (Germany) - Characterizing drug targets using CRISPR/Cas9 screens in PDX leukemia models in vivo
    • Aurélie BEDEL, BoRdeaux Institute of Oncology (BRIC), Bordeaux - CRISPR-Cas9 side effects: risk of genomic instability
    • Dominique HELMLINGER, Centre for Biochemical and Macromolecular Research (CRBM), Montpellier - New insights into transcription co-activator functions from conditional perturbations
    • Samuel AMINTAS, BoRdeaux Institute of Oncology (BRIC), Bordeaux - The CRISPR/CAS Technology for the detection of rare KRAS mutant alleles


  •  Therapeutic innovation and biomarkers : Flash Posters / Axis 3 session
    Chairs: Véronique GIGOUX & Fabrice LALLOUE
    • Diego BARBA, Montpellier Cancer Research Institute (IRCM), Montpellier - Development of pH-modulated antibodies, that recognize immune system checkpoints.
    • Marie BOUTAUD, Control of cell Activation in Tumor Progression and Therapeutic Resistance, (CAPTuR) Limoges - Metformin Treatment Reduces CRC Aggressiveness in a Glucose-Independent Manner: An In Vitro and Ex Vivo Study
    • David BRACQUEMOND, Montpellier Cancer Research Institute (IRCM), Montpellier - Overcoming osimertinib resistance in EGFR-driven-MET amplified lung cancer
    • Lydia DIF, Bordeaux Institute of Oncology (BRIC), Bordeaux - Fascin-1 inhibitors decrease hepatoblastoma cells tumorigenicity via YAP 1
    • Isabel GALEANO-OTERO, Bordeaux Institute of Oncology (BRIC), Bordeaux - Evaluation of tumor heterogeneity in colorectal cancer and its implication in metastatic process
    • Gaëlle GUILLON, Montpellier Cancer Research Institute (IRCM), Montpellier - Targeting the TNBC tumour microenvironment with Exatecan-conjugated anti-Cathepsin-D ADC
    • Leila KHAJAVI, Cancer Research Center of Toulouse (CRCT), Toulouse - Transcriptomic Profiling of the Non-Small Cell Lung Cancer (NSCLC) Microenvironment Identifies a Duality in Natural Killer Cell Behavior
    • Fang LIU, Montpellier Cancer Research Institute (IRCM), Montpellier - Improving the TA99 immunomodulatory effect with combination therapies using a new controlled delivery technology in oncology
    • Nicolas MATTEI, Pharmacology and Structural Biology Institute (IPBS), Toulouse - Study of irreversible electroporation-induced cell death in spheroids derived from a murine hepatoma cell line
    • Alexia MIRANDOLA, Montpellier Cancer Research Institute (IRCM), Montpellier - Persistence of netosis in resected colon cancer patient and impact on circulating DNA applications and post-surgery colon cancer management care
    • Léa RIMAILHO, Cancer Research Center of Toulouse (CRCT), Toulouse - Role of CD39 on ??T cells as a positive marker of anti-CD20-induced ADCC of non-Hodgkins lymphoma cells
    • Mathis TRIQUARD, PROgression et DIssémination CErébrales des cellules Tumorales (PRODICET) Poitiers University, Poitiers - Role of Exosomes in the Brain Dissemination of Tumor Cells derived form Breast Cancer (Locoregional and Distant)


  •  Health technologies: Flash Posters / Axis 5 session
    Chairs: Audrey FERRAND and Bertrand LIAGRE
    • Israa AL JAMAL, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Poitiers - Study of cellular communication processes induced by artificial cell-cell interactions for the development of novel cell-based therapy
    • Chloé BAZILE, Cancer Research Center of Toulouse (CRCT), Toulouse - Therapeutic targeting of pro-tumoral Tumor-Associated Macrophage by vectorized anti-folate receptor beta magnetic nanoparticles
    • Manon PORTA, LIttoral, ENvironment and Societies (LIENSs), La Rochelle - Bioactive ?-Carrageenan oligosaccharides coated ferrite nanoparticles as potential anticancer nanodrugs
    • Marcelo HURTADO, Cancer Research Center of Toulouse (CRCT), Toulouse - Transcriptional regulatory networks unravel cell states from immune cell type deconvolution and uncovers cell niches predictive of cancer progression
    • Aurélien MAZET, Laboratory for the Bioengineering of Tissues (BioTis), Bordeaux - Bioprinting early-stage pancreatic cancer models: a new tool to decipher tumor initiation mechanisms
    • Camille DOUILLET, Photonics, Numerical and Nanosciences Laboratory (LP2N), Bordeaux - Gut-in-caps: exploring the biophysical cues that drive self-organization of Caco2 cells into patho-physiological models of the intestinal epithelium
    • Malvina MARKU, Cancer Research Center of Toulouse (CRCT), Toulouse - From gene regulatory network inference to dynamical modelling: revealing cell behaviour through network modelling in Chronic Lymphocytic Leukaemia



Thursday 23rd November

09:00 - 11:00 : Plenary session

  •  Chemistry & Cancer 
    Chairs: Bertrand LIAGRE and Philippe POURQUIER
    • KEYNOTE SPEAKER Dario NERI, ETH, Zürich (Switzerland) - From encoded combinatorial libraries to clinical-stage targeted therapeutics
    • Marie LOPEZ, ETaC, Toulouse and Institut des Biomolécules Max Mousseron (IBMM), Montpellier - GRP94 chaperone identified as a new target of adenosine-cytosine bisustrate analogues in cancer cells using affinity based chemical probes
    • Justine JOURNAUX, Toulouse Cancer Research Center (CRCT), Toulouse - Thermal and mechanical stresses generated by magnetic nanoparticles upon magnetic field exposure induce immunogenic cell death in pancreatic adenocarcinoma
    • David LEGER, Laboratoire des Agroressources, Biomolécules et Chimie pour l'Innovation en Santé (LABCiS), Limoges - Effects of metalation on the PDT activity of arene ruthenium porphyrin-based photosensitizers on prostate cancer
    • Sébastien BRITTONPharmacology and Structural Biology Institute (IPBS), Toulouse - Deciphering and exploiting the mechanism of action of a large family of natural and bioinspired cytotoxic lipids


14:00 - 16:00 : Parallel sessions organized by Cancéropôle GSO Axes

  •  Cell signaling, microenvironment and targeting / Axis 1 session
    Chairs: Violaine MOREAU and Antonio MARAVER
    • KEYNOTE SPEAKER Roger GOMIS, Institute for Research in Biomedicine, Barcelona (Spain) - ER+ breast cancer metastasis cell fate mapping
    • Benoît THIBAULT, Toulouse Cancer Research Center (CRCT), Toulouse - Inflammation-induced epithelial plasticity can be by-passed through Vps34 inactivation to limit pancreatic cancer initiation
    • Jennifer FALCONI, Institut de Recherche en Cancérologie de Montpellier (IRCM), Montpellier - Tumor-derived cytokine, Upd3, promotes gut atrophy in a Drosophila larvae model of cachexia
    • Thomas BOYER, Immunoconcept, Bordeaux - Immunosuppressive Myeloid Cells foster Cancer Stem Cell (CSC) emergence through TGF-?
    • Lucile ROUYER, BoRdeaux Institute of Oncology (BRIC), Bordeaux - Cancer cells transfer invasive properties through tracks
    • Gilles FAVRE, Toulouse Cancer Research Center (CRCT), Toulouse - In silico-based strategy for the discovery of direct small molecule inhibtors of mutant RAS


  •  Genome Dynamics & Expression / Axis 2 session
    Chairs: Jean-Christophe ANDRAU and Derek McCUSKER
    • KEYNOTE SPEAKER Francis BARR, Trinity College & University of Oxford, Oxford (United Kingdom) - Mitotic mechanisms generating and sensing aneuploidy
    • Frédéric BECKOUET, Center for Integrative Biology (CBI), Toulouse - Mechanisms regulating cohesin dependent loops
    • Nezih KARASU, Institute of Molecular Genetics of Montpellier (IGMM), Montpellier - G-quadruplexes involvement in mammalian genome organization and stability
    • Sophie PERON, Control of the Immune B Response and Lymphoproliferations (CRIBL), Limoges - IgH 3'RR recombination uncovers a non-germinal center imprint and c-MYC-dependent IgH rearrangement in unmutated chronic lymphocytic leukemia
    • Domitille CHALOPIN-FILLOT, Institute of Cellular Biochemistry and Genetics (IBGC), Bordeaux - Exploiting the dark matter of single-cell transcriptomes to encompass suppressive myeloid cell differentiation in hepatocellular carcinoma


  • Nouveaux dispositifs numériques (in french)  / session Axe 4
    • 1 orateur invité
    • 3 communications sélectionnées


17:00 - 18:30 : Plenary session


  •  Environmental stress 
    Chair: Cyrille DELPIERRE
    • KEYNOTE SPEAKER Marc CHADEAU-HYAM, Imperial College, London (United Kingdom) -  Exposome Analytics: Definitions, Challenges and Applications


18:30 - 19:30 :

  •  Prestige conference
    • KEYNOTE SPEAKER Jacques ARNOULD, French Spatial Agency (CNES), Toulouse


Friday 24th November

08:30 - 10:00 : Parallel sessions organized by Cancéropôle GSO Axes

  •  Immunotherapy / Axis 1 & Axis 3 session
    Chairs: Abdel-Majid KHATIB & Bruno SEGUI
      • KEYNOTE SPEAKER Joan SEOANE, Vall d'Hebron Institute of Oncology (VHIO) & Universitat Autònoma de Barcelona (UAB), Barcelona (Spain) - Understanding the impact of the tumor microenvironment on immunotherapies
      • Nicolas LARMONIER, BoRdeaux Institute of Oncology (BRIC), Bordeaux - The multifaceted tumor-promoting functions of myeloid cells
      • Ludovic MARTINET, Toulouse Cancer Research Center (CRCT), Toulouse - T cell Immunotherapy: thinking beyond inhibitory receptors
      • Camille DANTZER, BoRdeaux Institute of Oncology (BRIC), Bordeaux - Repression of exosome secretion by mutated ß-catenin contributes to immune escape in hepatocellular carcinoma


  • Patients fragiles ou patients vulnérables (1) (in french)  / session Axe 4
    • 1 orateur invité
    • 2 communications sélectionnées


10:45 - 12:30: Plenary session and session Axe 4

  • Alternative models to animal testing
    Chairs: Audrey FERRAND and Gaëlle RECHER 
    • KEYNOTE SPEAKER Agathe FIGAROL, Institut FEMTO-ST, Besançon - Development of a physiological microsystem, from a blood-brain barrier-on-chip to a vascularized glioblastoma-on-chip
    • Léa MAGNE, Institut de Recherche en Santé Digestive (IRSD), Toulouse - Mechanical interplays between mitotic spindle orientation of colonic epithelial cells and extracellular matrix deformations
    • Margot MACHU, Institut de Recherche en Cancérologie de Montpellier (IRCM), Montpellier - Combination of immune checkpoint inhibitors with chemotherapies in new biological models of upper tract urothelial carcinomas
    • Alexia DE CARO, Institute of Pharmacology and Structural Biology (IPBS), Toulouse - Anti-tumor efficacy of new high-frequency electrical protocols in a 3D in vitro colorectal cancer model
    • Thomas BESSEDE, Institut de Recherche en Cancérologie de Montpellier (IRCM), Montpellier - Sensitizing the PDAC tumor microenvironment to immune checkpoint therapies: characterization of a PDAC 3D model to decipher immune infiltration
    • Joudi EL MIR, BoRdeaux Institute of Oncology (BRIC), Bordeaux - Xenopus laevis is an attractive model for studying the pigmentary abnormalities in xeroderma pigmentosum type C


  • Patients fragiles ou patients vulnérables (2) (in french)  / session Axe 4
    • 1 orateur invité
    • 2 communications sélectionnées