Canceropole-GSO

THURSDAY JULY 4

13:30
14:00

Attendees Welcome
Welcome Address
SESSION 1 : TRANSCRIPTION AND RECOMBINATION

♦ LECTURE - Chromatin structure as a mediator of transcription- and R-loop- associated recombination, Andres AGUILERA (CABIMER, Sevilla)

 14:45
15:10
15:35

• Transcriptionally active chromatin channels DNA double-strand breaks to RAD51-dependent repair, Gaelle LEGUBE (LBCMCP, Toulouse)
• Sense and anti-sense transcription during V(D)J recombination, Amine KHAMLICHI (IPBS, Toulouse)
• Immunoglobulin genes remodeling relies on intricate enhancer/transcription crosstalks, Eric PINAUD (CRIBL, Limoges)

 16h00

 Break

SESSION 2 : RNA PROCESSING AND R-LOOPS

♦ LECTURE - Widespread R-loop formation in human genes, Frederic CHEDIN (UC Davis)

 17:35
18:00

• Specific RNA processing factors influence mitotic chromosome organization by modulating the recruitment of the Condensin complex, Vincent VANOOSTHUYSE (ENS, Lyon)
• Involvement of a factor implicated in regulation of  mRNA nuclear export at the nuclear pore in maintenance of genome stability, Domenico MAIORANO (IGH, Montpellier)

18:25

 ♦ LECTURE - RNAi and Cenp-B coordinate DNA replication and epigenetic modification in heterochromatin, Rob MARTIENSSEN (Cold Spring Harbor)

19:00

Buffet - Genopolys

FRIDAY JULY 5

SESSION 3 : DNA REPLICATION

 ♦ LECTURE - The lysine specific demethylases, Lsd1/2, are required for replication fork pauses and asymmetric cell division, Benoit ARCANGIOLI (Pasteur, Paris)

 09:35
10:00
10:25

• Replisome surveillance by Fanconi anemia proteins and their interacting partners, Angelos CONSTANTINOU (IGH, Montpellier)
• INO80 promotes extraction of ubiquitinated RNA Polymerase II from chromatin to coordinate genome stability and transcription, Manolis PAPAMICHOS-CHRONAKIS (Curie, Paris)
• Deciphering the roles of replication and transcription on Common Fragile Site instability, Benoit LE TALLEC (Curie, Paris)

 SESSION 4 : RNA PROCESSING AND CANCER

 ♦ LECTURE - Deciphering Splicing regulators of tissue-specific splicing in both normal and cancer tissues, Jamal TAZI (IGMM, Montpellier)

11:55
12:20

• Beyond the RNA: the role of epigenetics in alternative splicing regulation, Reini LUCO (IGH, Montpellier)
• Co-operation between Microprocessor and RNA processing factors induces premature termination of transcription by RNAPII, Rosemary KIERNAN (IGH, Montpellier)

SESSION 5 : GENOME INSTABILITY

♦ LECTURE - RNA Processing Defects and Genome Instability, Karlene CIMPRICH (Stanford)

14:35
15:00

• ELL, a new partner of TFIIH, plays a role in transcription restart after DNA repair, Ambra GIGLIA-MARI (IPBS, Toulouse)
• Interference between replication and transcription in budding yeast, Philippe PASERO (IGH, Montpellier)

 15:25

Enf of the mini-symposium