Canceropole-GSO

THURSDAY APRIL 18

13h30

GENOMIC INSTABILITY AND EPIGENETICS

♦ LECTURE - Common fragile sites, large genes and chromosome instability in cancers, Michelle DEBATISSE (CNRS UMR 3244, Univ. Pierre et Marie Curie, Paris)

• DNA polymerase h - dependent DNA synthesis regulates fragile site stability by preventing under-replicated DNA in mitosis, Jean-Sébastien HOFFMANN (CRCT, Toulouse)
• Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas, Frédéric CHIBON (Inserm U916, Bordeaux)
• Differential and dynamic epigenetic control of cellular proliferation, signalling and tumourigenesis by polycomb complexes during drosophila development, Anne-Marie MARTINEZ (IGH, Montpellier)

15h20

HEMATOLOGICAL MALIGNANCIES AND CHROMOSOMAL REARRANGEMENTS (1/2)

• Recent advances in hematological malignancies, Christian Récher (CRCT et CHU, Toulouse)
• Extensive molecular mapping of TCRalpha/delta and TCRbeta involved in chromosomal translocations reveals distinct mechanims of oncogenes activation in T-ALL, Sandrine Le Noir (CRIBL, Limoges)

 16h10

 Break & Posters visit

17h00

HEMATOLOGICAL MALIGNANCIES AND CHROMOSOMAL REARRANGEMENTS (2/2)

• DNA double strand break repair constricted MCM8- and MCM9- deficient mice develop myeloproliferative neoplasms, Malik LUTZMANN (IGH, Montpellier)
• NF-kappa B and B-cell lymphomas, Jean FEUILLARD (CNRS et CHU, Limoges)
• Matrix Attachment Regions flanking the Eµ enhancer are critical cis- and trans- regulators of somatic hypermutation, Eric PINAUD (CRIBL, Limoges)
• The immunoglobulin heavy chain 3’ regulatory region controls somatic hypermutation in germinal centre B-cells, Pauline ROUAUD (CRIBL, Limoges)

 ♦ LECTURE - Description and analysis of genetic alterations in lymphomas - Relations with phenotype and clinical behavior, Christian BASTARD (CLCC, Rouen)

20h30

Cocktail - Mercure Compans Cafarelli

FRIDAY APRIL 19

09h00

NON CODING RNAs

 ♦ LECTURE - Impact of hypomethylation and transcription of repeated sequences on abnormal cellular and nuclear phenotypes, Claire FRANCASTEL (Université Paris Diderot, CNRS UMR7216, Paris)

• Long non coding RNAs as a source of microRNAs and small nucleolar RNAs in hematopoietic cancers, Pierre BROUSSET (CRCT et CHU, Toulouse)
• The role of epigenetics and lncRNAs in cell-specific alternative splicing, Reini LUCO (IGH, Montpellier)
• Study of the transcription of the IgH locus 3’ regulatory region (3\'RR) during the maturation of B lymphocytes, Sophie PERON (CRIBL, Limoges)
• High throughput screenings of molecular compounds with the potential to interfere with microRNA biogenesis, Jérôme CAVAILLE (LBME, Toulouse)

 BIOMARKERS

• Predictive vs pronostic biomarkers and evaluation of response to a drug, Antoine ITALIANO (Institut Bergonié, Bordeaux)
• A blood-signature CDx in Pancreas Cancer treatment, David PIQUEMAL(Skuldtech, Montpellier)
• Role of RECQ1 helicase in Multiple Myeloma physiopathology and drug resistance, Jérôme MOREAUX (IRB, Montpellier)

DNA REPAIR AND TELOMERES

• NR2C/F proteins target telomere/genome rearrangements in ALT cells, Jérôme DEJARDIN (IGH, Montpellier)
• Transcription-dependent DNA double-strand breaks produced by topoisomerase I-targeting drugs: characterization and cellular detection using tripartite split-GPF, Olivier SORDET (CRCT, Toulouse)
• DNA dynamics during early double-strand break processing revealed by non-intrusive imaging of living cells, Hicham SAAD (LBME, Toulouse)

♦ From HIV to Cancer, Monsef BENKIRANE (IGH, Montpellier)