Canceropole-GSO

THURSDAY APRIL 5

13h45

Session 1 : Transcription/RNAs

Opening lecture - A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
Brigitte BRESSAC DE-PAILLERETS, Laboratoire d'Oncogénétique, Institut Gustave Roussy et Inserm U946, Fondation Jean Dausset, Paris

H. pylori and gastric cancer: role of miRNAs in this intimate relationship
Fabien DARFEUILLE, Inserm U869, Bordeaux

Systematic identification of microRNAs controlling B-catenin expression through its untranslated regions in hepatoblastoma cells
Christophe GROSSET, Inserm U1053, Bordeaux

Identification and functional study of a new protein partner of the basal transcription/repair factor TFIIH
Sophies MOURGUES, IPBS, Toulouse

Regulation of nucleolar signalling by the ubiquitin-like molecule NEDD8
Dimitris P. XIRODIMAS, CRBM, Montpellier

16h45

Session 2 : Stem cells / reprogramming

Reprogramming Senescent Cells into pluripotent Stem Cells
Jean-Marc LEMAITRE, IGF, Montpellier

Elimination of brain cancer stem cells by targeting key transcription factors involved in self-renewal and differentiation
Jean-Philippe HUGNOT, INM, Montpellier

Deubiquitylating enzyme Dub3 links external signalling to the G1/S checkpoint in embryonic stem cells
Siem VAN DER LAAN, IGH, Montpellier

18h00

Session 3 : Epigenetics

piRNA-mediated transgenerational inheritance of an acquired trait
Séverine CHAMBEYRON, IGH, Montpellier

TIF1b and HP1 in the epigenetic control of cell differentiation
Florence CAMMAS, Inserm U896, Montpellier

Targeting DNA methylation: design and conception of new inhibitors
Paola ARIMONDO, CNRS USR n°3388 ETaC CNRS-Pierre Fabre, Toulouse

20h30

Cocktail - Toulouse city center - Crowne Plaza

FRIDAY APRIL 6

09h00

Session 4 : Cell cycle

Cell elongation - an adaptive response clearing long chromatid arms from the cleavage site
Anne ROYOU, IECB, Bordeaux

Phosphorylation and ubiquitin-dependent inactivation of Fbw7a controls periodic expression of cyclin E
Olivier COUX, CRBM, Montpellier

Theranostics and Biology of Cyclin D1
Frédéric BIENVENU, IGF, Montpellier

New Tools for Old Targets : Fluorescent Biosensors to Probe Cyclin-Dependent Kinases
May MORRIS, CRBM, Montpellier

3D Structured Illumination Microscopy : imaging beyond the diffraction barrier
Julio MATEOS-LANGERAK, MRI, UMS3426, IGH, Montpellier

Live cell division dynamics monitoring in 3D large spheroid tumor models using light sheet microscopy
Valérie LOBJOIS, ITAV UMS 3039, Toulouse

Lecture - The FANC pathway: a guardian for a safely replication and the stability of fragile sites
Filippo ROSSELLI, IGR, Paris< trong>

Impact of ATR mutations on chromosome instability, DNA replication and chemoresistance.
Arnaud COQUELLE, Inserm U896, IRCM, Montpellier

MCM8 a MCM9 deficient mice revael gametogene ects and genome instability due to impaired homologous recombination
Malik LUTZMANN, IGH, MontpellieR

Genetic and epigenetic changes associated to early steps of cancer transformation
Anne SAUMET, IRCM, Montpellier

14h30

Session 7 : Synthetic lethality

Current issues in clinical development of new drugs combinations
Diego TOSI, CRLC Val D'Aurelle, Montpellier

Sumoylation and ROS: could they represent a novel therapeutic axis to treat chemoresistant Acute Myeloid Leukemia ?
Marc PIECHACZYK, IGMM, Montpellier

Closing Lecture - Structural and molecular insight into DNA replication stress
Massimo LOPES, Institute of Molecular Research, Zürich