Canceropole-GSO

THURSDAY FEBRUARY 27

14h00

TRANSCRIPTION AND CANCER

• The RNA binding protein hnRNP A1 regulates Ron mRNA translation and breast cancer metastasis, Anne CAMMAS (CRCT, Toulouse)
• microRNA titration by pseudo-targets: an alternative explanation to seed match conservation, Natalia PINZON-RESTREPO (IGH, Montpellier)
• Tyrosine phosphorylation of RNA Polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells, Jean-Christophe ANDRAU (IGMM, Montpellier)
• A developmental switch in the transcriptional activity of a long-range regulatory element in B lymphocytes, Ahmed Amine KHAMLICHI (IPBS, Toulouse)

16h00

Break & Posters visit

17h00

3R

  ♦ LECTURE - Genome-wide approaches to study the replication process – Use of the GALAXY web-based bioinformatic tool by a simple biologist, Jean-Charles CADORET (Institut Jacques Monod, Paris)

• Role for DNA Polymerase Theta in human DNA Replication timing, Laure GUITTON-SERT (CRCT, Toulouse)
• A new method for high-resolution imaging of Ku foci to decipher mechanisms and control of DNA double-strand break repair, Sébastien BRITTON (IPBS, Toulouse)
• Systematic analysis of proteins recruited to stalled forks, Cyril RIBEYRE (IGH, Montpellier)
• Histones demethylases and response to DNA damage, Yvan CANITROT (LBCMCP, Toulouse)

FRIDAY FEBRUARY 28

09h00

CANCER GENOMICS

• Next generation sequencing shows clonal selection after treatment with anastrozole or fulvestrant in a randomized trial of postmenopausal patients with large operable or locally-advanced hormone-receptor-positive breast cancer, Richard IGGO (Inserm U916, Bordeaux)
• A new integrative procedure to identify and explore new RNA in myeloid leukemia : from software development to biological validation, Thérèse COMMES (IRB, Montpellier)
• Fuzzy logic selection as a new reliable tool to identify gene signatures in breat cancers, Magali LACROIX (Institut Claudius Regaud, Limoges)
• From laboratory bench to patient, micro-arrays to NGS: clinical transfer of a gene expression signature, Tom LESLUYES (Inserm U916, Bordeaux)

 CELL CYCLE AND APOPTOSIS

• Greatwall kinase overexpression promotes cell transformation and increases tumour malignancy by promoting hyperactivation of Akt, Anna CASTRO (CRBM, Montpellier)
• Polymeric nuclear actin drives nuclear assembly and DNA replication, Daniel FISHER (IGMM, Montpellier)
• Aurora B promotes telomere disjunction in mitosis by controlling the dissociation of Swi6/HP1 and condensin phosphorylation, Sylvie TOURNIER (LBCMCP, Toulouse)
• The ROS/SUMO axis regulates gene expression programs during Acute Myeloid Leukemia response to chemotherapeutic drugs, Guillaume BOSSIS (IGMM, Montpellier)

TRANSCRIPTION AND NUCLEOSOME DYNAMICS

♦ Lecture: MITF-regulation of gene expression and cell heterogeneity in melanoma, Irwin DAVIDSON (IGBMC, Strasbourg)

• GATA2 alterations in acute myeloid leukemia and myelodysplasia, Cyril BROCCARDO (CRCT, Toulouse)
• Functional insights into epigenetic regulation of oncogenes through biostatistical analyses of nucleosome positioning and chromosome architecture, Olivier CUVIER (LBME, Toulouse)